반응 #10590

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Intermediate 6

N-(tert-butoxycarbonyl)-N′-[(5-isoquinolyl)sulfonyl]-N′-(4-phenylbutyl)-1,3-propylenediamine

hydrogen chloride methanol

→

title compound

N-[(5-isoquinolyl)sulfonyl]-N-(4-phenylbutyl)-1,3-propylenediamine hydrochloride

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후처리

1. 1
   기타(50° C., 2 hours)
2. 2
   기타the solvent was evaporated under reduced pressure
3. 3
   workup.ADDITIONThe residue was added with methanol (1 ml) and diethyl ether (3 ml)
4. 4
   기타The deposited precipitates
5. 5
   여과were collected by filtration
6. 6
   세척washed with diethyl ether

실험 절차

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 6 (249 mg) and 10% hydrogen chloride/methanol solution (5 ml). The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. The residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (188 mg) as white powdery solid.

출처