반응 #1057998

반응 방정식

5-Bromomethyl-2-phenylbenzoxazole

cesium acetate

→

acetic acid 2-phenylbenzoxazol-5-ylmethyl ester

수율 101.2%

Acetic acid 2-phenylbenzoxazol-5-ylmethyl ester

수율 101.2%

용매

DMF

반응 조건

후처리

1. 1
   기타The DMF was evaporated under high vacuum
2. 2
   기타the residue partitioned between ethyl acetate (100 ml) and water (100 ml)
3. 3
   기타The ethyl acetate layer was separated
4. 4
   세척then washed
5. 5
   기타dried
6. 6
   기타Evaporation of the solvent

실험 절차

5-Bromomethyl-2-phenylbenzoxazole 56 (1.0 g, 3.4 mmol) and cesium acetate (1.33 g, 6.94 mmol) were stirred together in DMF(25 ml) under an atmosphere of N2 overnight. The DMF was evaporated under high vacuum and the residue partitioned between ethyl acetate (100 ml) and water (100 ml). The ethyl acetate layer was separated then washed and dried. Evaporation of the solvent yielded 920 mg of acetic acid 2-phenylbenzoxazol-5-ylmethyl ester 57.

출처