반응 #1057997

반응 방정식

5-methyl-2-phenylbenzoxazole

5-Methyl-2-phenylbenzoxazole

NBS

→

5-bromomethyl-2-phenylbenzoxazole

수율 70.6%

5-Bromomethyl-2-phenylbenzoxazole

수율 70.6%

용매

carbon tetrachloride

반응 조건

후처리

1. 1
   기타The mixture was evacuated
2. 2
   기타flushed with argon
3. 3
   workup.ADDITIONAIBN (ca. 5 mg) was added
4. 4
   온도the mixture heated
5. 5
   온도at reflux
6. 6
   기타irradiated with a sun lamp for 3 hrs
7. 7
   기타The solvent was evaporated under reduced pressure
8. 8
   기타the residue purified by chromatography

실험 절차

5-methyl-2-phenylbenzoxazole 55 (1.23 g, 5.8 mmol) and NBS (1.17 g, 6.5 mmol) were dissolved in carbon tetrachloride (20 ml). The mixture was evacuated and flushed with argon. AIBN (ca. 5 mg) was added and the mixture heated at reflux and irradiated with a sun lamp for 3 hrs. The solvent was evaporated under reduced pressure and the residue purified by chromatography to yield 1.18 g of 5-bromomethyl-2-phenylbenzoxazole 56.

출처