반응 #1056872

반응 방정식

lithium

2-(quinazolin-6-ylamino)-benzoic acid

4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-7-ylamine

TBTU

DIEA

→

N-(4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-7-yl)-2-(quinazolin-6-ylamino)-benzamide

용매

Water

DMF

반응 조건

후처리

1. 1
   기타was submitted to microwave irradiation (80° C., 30 min)
2. 2
   여과the resultant precipitate was filtered
3. 3
   기타dried
4. 4
   기타The crude material was purified with flash chromatography (SiO2, 50% EtOAc/hexane)
5. 5
   기타to afford a white solid

실험 절차

A mixture of the lithium salt of 2-(quinazolin-6-ylamino)-benzoic acid (Step B, 533 mg, 0.72 mmol), 4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-7-ylamine (127 mg, 0.72 mmol), TBTU (462 mg, 1.44 mmol) and DIEA (0.25 mL, 1.44 mmol) in 3 mL of DMF was submitted to microwave irradiation (80° C., 30 min). Water (5 mL) was added to the mixture, and the resultant precipitate was filtered and dried. The crude material was purified with flash chromatography (SiO2, 50% EtOAc/hexane) to afford a white solid. MS (ES+): 424.0 (M+H)+. Calc'd for C26H25N5O: 423.51.

출처