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(R)-4-(3-hydroxy-2-methylpropyl]-4H-benzo[1,4]oxazin-3-one

(R)-4-(3-Hydroxy-2-methylpropyl]-4H-benzo[1,4]oxazin-3-one

triphenylphosphine

imidazole

iodine

→

crude title compound

수율 20.0%

(R)-4-(3-Iodo-2-methylpropyl]-4H-benzo[1,4]oxazin-3-one

수율 20.0%

용매

CHCl3

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실험 절차

Crude (R)-4-(3-hydroxy-2-methylpropyl]-4H-benzo[1,4]oxazin-3-one (108LM40-37) (1.040 g), triphenylphosphine (0.99 g, 3.77 mmol), imidazole (0.32 g, 4.71 mmol) and iodine (1.43 g, 5.65 mmol) in CHCl3 (30 mL) were reacted according to GP4 to give the crude title compound (108LM46-43) (0.312 g).

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