반응 #10535

반응 방정식

6-[(2,2-diphenylethyl)amino]-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2-carbonitrile

hydrochloric acid

→

title compound

수율 99.6%

6-[(2,2-Diphenylethyl)amino]-9H-purine-2-carbonitrile

수율 99.6%

용매

ethanol

반응 조건

후처리

1. 1
   기타The solvent was removed under reduced pressure
2. 2
   workup.DISSOLUTIONthe residue dissolved in ethanol
3. 3
   기타the solvent again removed under reduced pressure
4. 4
   기타The residue was triturated with diethyl ether
5. 5
   여과filtered
6. 6
   세척washed with diethyl ether and pentane
7. 7
   기타dried

실험 절차

A solution of 6-[(2,2-diphenylethyl)amino]-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2-carbonitrile (Preparation 5) (17 g, 40.1 mmol) in ethanol (850 ml) was treated with 2 N aqueous hydrochloric acid (50 ml) and the mixture stirred at room temperature for 24 hours. The solvent was removed under reduced pressure, the residue dissolved in ethanol and the solvent again removed under reduced pressure. The residue was triturated with diethyl ether, filtered, washed with diethyl ether and pentane, and dried to afford the title compound as a solid (13,6 g).

출처