반응 #10519

반응 방정식

(2S,5S)-5-(2-benzylamino-2-carboxyethyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

hydrogen

→

(2S,5S)-5-(2-amino-2-carboxyethyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester hydrogen acetate

용매

acetic acid

반응 조건

후처리

1. 1
   여과The catalyst was filtered off through kieselguhr
2. 2
   세척the filter cake was washed with 20 ml of acetic acid
3. 3
   농축The combined organic phases were concentrated in vacuo
4. 4
   기타The crude product was employed without further purification in the next reaction

실험 절차

1600 mg of (2S,5S)-5-(2-benzylamino-2-carboxyethyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester were dissolved in 30 ml of acetic acid. 100 mg of 20% palladium hydroxide on activated carbon were added thereto, and the mixture was hydrogenated under an atmosphere of 1 bar of hydrogen for 1 h. Ar was then passed over the solution for 10 min. The catalyst was filtered off through kieselguhr and the filter cake was washed with 20 ml of acetic acid. The combined organic phases were concentrated in vacuo. The crude product was employed without further purification in the next reaction.

출처