반응 #10507

반응 방정식

5-bromo-2-[2-(2-(R)-methyl-pyrrolidin-1-yl)-ethyl]-1H-indole

Cs2CO3

CsF

4-cyanophenylboronic acid

2-dicyclohexylphosphino(biphenyl)

→

title compound

수율 44.9%

4-{2-[2-(2-(R)-Methyl-pyrrolidin-1-yl)-ethyl]-1H-indol-5-yl}-benzonitrile

수율 44.9%

용매

H2O

toluene

반응 조건

후처리

1. 1
   기타The resulting mixture was purged with nitrogen
2. 2
   기타The resulting reaction mixture
3. 3
   기타was consumed
4. 4
   온도The reaction mixture was cooled to room temperature
5. 5
   workup.ADDITIONIPAc (20 mL) was added
6. 6
   기타The organic layer was separated
7. 7
   농축concentrated
8. 8
   기타The residue was purified by column chromatography
9. 9
   세척eluting with heptane/acetone/CH2Cl2/Et3N (600 mL/40 mL/5 mL/2 mL)
10. 10
    workup.ADDITIONThe fractions containing product
11. 11
    농축concentrated under reduced pressure

실험 절차

A reaction flask was charged with Cs2CO3 (1.14 g, 3.5 mmol), CsF (0.38 g, 2.5 mmol), 4-cyanophenylboronic acid (425 mg, 2.5 mmol), and H2O (10 mL) followed by a toluene solution (10 mL) of 5-bromo-2-[2-(2-(R)-methyl-pyrrolidin-1-yl)-ethyl]-1H-indole (307 mg, 1.0 mmol). The resulting mixture was purged with nitrogen. To the reaction mixture was then added 2-dicyclohexylphosphino(biphenyl) (35 mg, 0.1 mmol) and Pd2(dba)3 (46 mg, 0.05 mmol). The resulting reaction mixture was then heated to 65° C. overnight under nitrogen after which HPLC indicated that all the 5-bromo-2-[2-(-(R)-methyl-pyrrolidin-1-yl-ethyl]-1H-indole was consumed. The reaction mixture was cooled to room temperature and IPAc (20 mL) was added. The organic layer was separated and concentrated. The residue was purified by column chromatography eluting with heptane/acetone/CH2Cl2/Et3N (600 mL/40 mL/5 mL/2 mL). The fractions containing product were combined and concentrated under reduced pressure to provide the title compound as a semi-solid (148 mg). 1H NMR (400 MHz, CDCl3) δ 10.22 (s, 1H), 7.65–7.74 (m, 5H), 7.40 (d, J=8.5 Hz, 1H), 7.33 (dd, J=1.8, 8.5 Hz, 1H), 6.27 (s, 1H), 3.37–3.42 (m, 1H), 3.21–3.25 (m, 1H), 3.01–3.16 (m, 2H), 2.54–2.62 (m, 2H), 2.33 (q, J=8.78Hz, 1H), 2.04–2.08 (m, 1H), 1.80–1.93 (m, 2H), 1.56–1.63 (m, 1H), 1.21 (d, J=6.2 Hz, 3H). 13C NMR (400 MHz, CDCl3) δ 146.99, 139.96, 135.61, 132.05, 130.30, 128.74, 127.32, 120.02, 119.13, 118.36, 111.13, 109.16, 99.49, 61.25, 53.68, 53.57, 32.92, 26.21, 22.14, 18.98. [M+H]+ at m/z 330.

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