반응 #10481

반응 방정식

1-(4-methylphenyl)-1,2-cyclopropanedicarboxylic acid

urea

→

(±)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexan-2,4-dione

용매

toluene

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도to reflux
3. 3
   온도at reflux until the reaction
4. 4
   기타On completion of the reaction period
5. 5
   온도the solution was cooled to 80–90° C.
6. 6
   세척washed with water (69 L)

실험 절차

A mixture of purified 1-(4-methylphenyl)-1,2-cyclopropanedicarboxylic acid (58 kg), toluene (465 kg) and urea (23.8 kg) was heated to reflux and the mixture held at reflux until the reaction was complete. On completion of the reaction period, the solution was cooled to 80–90° C. and washed with water (69 L). The lower aqueous layer was discarded. In this way (±)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexan-2,4-dione was obtained as a solution in toluene.

출처