반응 #10464

반응 방정식

N-(aminocarbonothioyl)-3-chloro-2-methylbenzenesulfonamide

methyl 3-bromo-4-oxobutanoate

→

Methyl (2{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-5-yl)acetate

용매

pyridine

반응 조건

후처리

1. 1
   기타were irradiated in a microwave oven for 2.5 min at 130° C
2. 2
   기타The solvent was removed under reduced pressure
3. 3
   기타the product separated from the starting materials

실험 절차

N-(aminocarbonothioyl)-3-chloro-2-methylbenzenesulfonamide (0.4 g, 1.5 mmol) and methyl 3-bromo-4-oxobutanoate (0.3 g, 1.5 mmol), dissolved in pyridine (5 mL), were irradiated in a microwave oven for 2.5 min at 130° C. The solvent was removed under reduced pressure and the product separated from the starting materials using preparative HPLC (yield 0.2 g, 30%).

출처