반응 #10458

반응 방정식

1,3-dibenzylpyrrolidine-3-carboxylic acid ethyl ester

NaOH

→

title compound

수율 76.8%

1,3-Dibenzylpyrrolidine-3-carboxylic acid

수율 76.8%

용매

methanol

반응 조건

후처리

1. 1
   온도the reaction is heated
2. 2
   온도to reflux for 24 hours
3. 3
   온도The solution is cooled
4. 4
   농축concentrated
5. 5
   workup.DISSOLUTIONredissolved in water
6. 6
   추출extracted with ether
7. 7
   기타the precipitated solid is collected

실험 절차

To a solution of 1,3-dibenzylpyrrolidine-3-carboxylic acid ethyl ester (Example A18e, 13.1 g, 41 mmol) in 250 mL of methanol is added 2N NaOH (46 mL, 92 mmol) and the reaction is heated to reflux for 24 hours. The solution is cooled, concentrated, redissolved in water and extracted with ether. The pH of the aqueous layer is adjusted to 7 and the precipitated solid is collected, to give 9.3 g of the title compound, MS EI+: m/z 296 (MH+), mp 209–210° C.

출처