반응 #1045

반응 방정식

2,3,3-trifluoro-2-propenyl bromide

triethyl phosphite

→

diethyl (1,1,2-trifluro-2-propenyl)phosphonate

수율 11.0%

diethyl (2,3,3-trifluro-2-propenyl)phosphonate

수율 14.0%

반응 조건

후처리

1. 1
   온도at reflux for overnight
2. 2
   기타The residue obtained
3. 3
   기타after evaporation of the solvent
4. 4
   기타was chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1)

실험 절차

A solution of 2,3,3-trifluoro-2-propenyl bromide (5.25 g, 30 mmol) and triethyl phosphite (4.15 g, 25 mmol) in acetonltrile (15 mL) was heated at reflux for overnight. The residue obtained after evaporation of the solvent was chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1) to give diethyl (1,1,2-trifluro-2-propenyl)phosphonate (0.8 g, 11%) and diethyl (2,3,3-trifluro-2-propenyl)phosphonate (1.0 g, 14%).

출처