반응 #1044

반응 방정식

1,2,4-triazole

3,4,4-trifluoro-3-butenoyl chloride

→

desired product

수율 94.2%

1-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole

수율 94.2%

용매

ethyl acetate

반응 조건

후처리

1. 1
   workup.STIRRINGThe mixture was stirred for 30 min
2. 2
   여과filtered
3. 3
   기타The residue obtained
4. 4
   기타after evaporation of the solvent
5. 5
   workup.DISSOLUTIONwas redissolved in dichloromethane (25 mL)
6. 6
   여과filtered
7. 7
   기타Evaporation of the solvent

실험 절차

To a solution of 1,2,4-triazole (1.38 g, 20 mmol) in ethyl acetate (100 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (1.59 g, 10 mmol) at r.t. with stirring. The mixture was stirred for 30 min and filtered. The residue obtained after evaporation of the solvent was redissolved in dichloromethane (25 mL) and filtered. Evaporation of the solvent gave 1.8 g (94%) of the desired product as a dear oil.

출처