반응 #1043

반응 방정식

trifluoromethanesulfonamide

3,4,4-trifluoro-3-butenoyl chloride

→

desired product

수율 16.4%

3,4,4-trifluoro-N-[(trifluoromethyl)sulfonyl]-3-butenamide

수율 16.4%

용매

sodium hydroxide

반응 조건

후처리

1. 1
   workup.STIRRINGThe mixture was stirred in cold for 30 min
2. 2
   기타the white precipitate formed
3. 3
   여과was filtered
4. 4
   세척washed with cold water (10 mL)
5. 5
   기타dried

실험 절차

To an ice-cooled solution of trifluoromethanesulfonamide (2.75 g, 18.4 mmol) in 7.4 mL of 2.5 N sodium hydroxide was added 3,4,4-trifluoro-3-butenoyl chloride (2.93 g, 18.5 mmol) with stirring in 2 min. The mixture was stirred in cold for 30 min and the white precipitate formed was filtered, washed with cold water (10 mL) and dried to give 0.82 g (16%) of the desired product as a white solid. m.p. 115°-120° C.

출처