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3-{[(4-fluorophenyl)sulfonyl]methyl}azetidine hydrochloride

3-{[(4-Fluorophenyl)sulfonyl]methyl}azetidine hydrochloride

2-bromo-1-(3-thienyl)ethanone

→

2-(3-{[(4-Fluorophenyl)sulfonyl]methyl}azetidin-1-yl)-1-(3-thienyl)ethanone

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후처리

1. 1
   기타Prepared

실험 절차

Prepared according to the method of Example 2 using 3-{[(4-fluorophenyl)sulfonyl]methyl}azetidine hydrochloride (Example 1 Step 4) and 2-bromo-1-(3-thienyl)ethanone. 1H NMR (500 MHz, d6-DMSO) δ 10.51 (1H, s), 8.52 (1H, s), 7.96 (2H, dd, J=5.1, 8.7 Hz), 7.72 (1H, dd, J=2.8, 5.0 Hz), 7.55 (2H, t, J=8.8 Hz), 7.49 (1H, d, J=4.3 Hz), 4.91 (2H, s), 4.19 (2H, s), 4.00 (2H, s), 3.82 (2H, d, J=6.7 Hz), 3.10–3.03 (1H, m); m/z (ES+) 354 (M+H)+.

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