반응 #1032

반응 방정식

1-hydroxybenzotriazole

(S)-4-amino-5-chloro-2-[(1-methyl-2-butynyl)oxy]benzoic acid

8-amino-3-benzylazabicyclo[3.2.1]octane

WSC.HCl

→

title compound

(S)-N-(3-Benzyl-3-azabicyclo[3.2.1 ]oct-8-yl)-4-amino-5-chloro-2-(1-methyl-2-butynyl)oxybenzamide

반응 조건

후처리

1. 1
   기타The product was purified by silica gel column chromatography (5% methanol/chloroform)

실험 절차

The condensation of 530 mg of (S)-4-amino-5-chloro-2-[(1-methyl-2-butynyl)oxy]benzoic acid with 850 mg of 8-amino-3-benzylazabicyclo[3.2.1]octane was conducted in a similar manner to that of the Example 34 by the use of WSC.HCl and 1-hydroxybenzotriazole (HOBT). The product was purified by silica gel column chromatography (5% methanol/chloroform) to give 220 mg of the title compound.

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