반응 #10303

반응 방정식

water

Sodium hydride

4-fluorobenzenethiol

5-(diphenylmethyl)-1-oxa-5-azaspiro[2.3]hexane

→

title product

수율 80.0%

1-(Diphenylmethyl)-3-{[(4-fluorophenyl)thio]methyl}azetidin-3-ol

수율 80.0%

용매

THF

THF

반응 조건

후처리

1. 1
   온도cooled to 0° C
2. 2
   workup.ADDITIONwas added
3. 3
   workup.STIRRINGthe resulting mixture stirred at −1° C. for 40 min
4. 4
   기타at room temperature
5. 5
   기타overnight
6. 6
   추출extracted with EtOAc (100 mL
7. 7
   세척The organic extracts were washed with saturated brine (100 mL)
8. 8
   건조dried (MgSO4)
9. 9
   농축concentrated
10. 10
    기타The residue was purified by flash silica chromatography
11. 11
    세척eluting with 25% EtOAc/isohexane

실험 절차

Sodium hydride (0.128 g of a 60% dispersion in mineral oil, 3.2 mmol) was added to a solution of 4-fluorobenzenethiol (0.29 mL, 2.7 mmol) in THF (10 mL). The resulting mixture was stirred at room temperature for 10 min and then cooled to 0° C. A solution of 5-(diphenylmethyl)-1-oxa-5-azaspiro[2.3]hexane [prepared by the method of J. L. Castro Pineiro et al. WO 97/42189] (0.68 g, 2.71 mmol) in THF (8 mL) was added and the resulting mixture stirred at −1° C. for 40 min then at room temperature overnight. The reaction mixture was poured into water (200 mL) and extracted with EtOAc (100 mL then 50 mL). The organic extracts were washed with saturated brine (100 mL), combined, dried (MgSO4) and concentrated. The residue was purified by flash silica chromatography, eluting with 25% EtOAc/isohexane, to give the title product as an oil (0.82 g, 80%). 1H NMR (400 MHz, CDCl3) δ 2.67 (1H, s), 2.94–2.96 (2H, m), 3.18–3.20 (2H, m), 3.43 (2H, s), 4.34 (1H, s), 6.96–7.02 (2H, m), 7.15–7.19 (2H, m), 7.23–7.26 (4H, m), 7.34–7.36 (4H, m), 7.41–7.46 (2H, m). (376 MHz, CDCl3) δF −115.2. m/z (ES+) 380 (M+H)+.

출처