반응 #1029

반응 방정식

2-acetyl-4-(pyrid-2-yl)-pyrimidine

hydroxylamine

sodium acetate

→

2-acetyl-4-(pyrid-2-yl)-pyrimidine oxime

수율 91.1%

용매

water

ethanol

water

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도to reflux for 1.5 hours
3. 3
   여과filtered
4. 4
   세척washed with hexane

실험 절차

A solution of 2-acetyl-4-(pyrid-2-yl)-pyrimidine (1.0 g), hydroxylamine (0.39 g) and sodium acetate (0.62 g) in a mixture of ethanol (10 ml) and water (2 ml) was heated to reflux for 1.5 hours. The reaction was then poured into water the precipitate filtered and washed with hexane to give 2-acetyl-4-(pyrid-2-yl)-pyrimidine oxime (0.98 g, 91% yield) as a white crystalline solid m.p. 196°-8° C.; 1H NMR: 2.50(3H,s); 7.42(1H,m); 7.88(1H,m); 8.30(1H,d); 8.59(1H,d); 8.74(1H,d); 8.90(1H,d); 10.85(1H,brs) ppm.

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