반응 #1028

반응 방정식

3-acetyl-isoquinoline

hydroxylamine

sodium acetate

→

3-acetyl-isoquinoline oxime

수율 89.0%

용매

water

methanol

water

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도to reflux for 1.5 hours
3. 3
   추출extracted with ethyl acetate
4. 4
   기타The combined extracts were dried
5. 5
   농축concentrated
6. 6
   기타triturated with hexane

실험 절차

A solution of 3-acetyl-isoquinoline (0.65 g), hydroxylamine (0.29 g) and sodium acetate (0.47 g) in a mixture of methanol (20 ml) and water (3 ml) was heated to reflux for 1.5 hours. The reaction was then poured into water and extracted with ethyl acetate. The combined extracts were dried, concentrated and triturated with hexane to give 3-acetyl-isoquinoline oxime (0.63, 89% yield) as a white crystalline solid m.p. 135°-142° C.; 1H NMR: 2.50(3H,s); 7.61(1H,t); 7.70(1H,t); 7.87(1H,d); 7.99(1H,d); 8.11(1H,s); 9.28(1H,s) ppm.

출처