반응 #10271

반응 방정식

water

[5-(morpholin-4-ylmethyl)-4,5-dihydro-isoxazol-3-yl]methanol

diisopropylethylamine

methanesulfonyl chloride

→

[5-((morpholin-4-yl)methyl)-4,5-dihydro-isoxazol-3-yl]methanol methanesulfonate

용매

dichloromethane

반응 조건

후처리

1. 1
   기타The layers were separated
2. 2
   건조the organic layer was dried (Na2SO4) en
3. 3
   농축concentrated in vacuo

실험 절차

To a solution of [5-(morpholin-4-ylmethyl)-4,5-dihydro-isoxazol-3-yl]methanol (0.38 g) in dichloromethane was added dropwise diisopropylethylamine (0.33 mL) and methanesulfonyl chloride (0.15 mL). The resulting solution was stirred at room temperature for 3 h and treated with water. The layers were separated and the organic layer was dried (Na2SO4) en concentrated in vacuo to afford [5-((morpholin-4-yl)methyl)-4,5-dihydro-isoxazol-3-yl]methanol methanesulfonate, 0.52 g (˜100%). Rf 0.63 (CH2Cl2/MeOH/NH4OH 92/7.5/0.5).

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