반응 #10215

ord-6961669486c8494bb2c3a3bdd60048e7

반응 방정식

N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
famotidine
N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
famotidine
NC(=O)c1ccncc1
isonicotinic acid amide
CC(O)C(=O)O
lactic acid
→
CC(O)C(=O)O.NC(=O)c1ccncc1
Isonicotinic Acid Amide Lactic Acid

반응물

N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
famotidine
N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
famotidine
NC(=O)c1ccncc1
isonicotinic acid amide
CC(O)C(=O)O
lactic acid

시약

없음

용매

O
water
O
water

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    workup.DISSOLUTIONto dissolve them
  2. 2
    workup.ADDITIONwas added
  3. 3
    기타a kinematic viscosity at room temperature of 0.95 centistokes was obtained

실험 절차

To 1 g of famotidine and 5 g of isonicotinic acid amide were added about 80 ml of water for injection and 2.20 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was added to make the total volume 100 ml, whereby an injection solution having a pH of 6.2 and a kinematic viscosity at room temperature of 0.95 centistokes was obtained.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07094414B2uspto-grants-2006_08