반응 #10202

반응 방정식

1-(10-Aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone

chlorosulfonic acid

→

oil

수율 87.0%

10-Trifluoroacetyl-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-4-sulfonyl chloride

수율 87.0%

반응 조건

후처리

1. 1
   기타The mixture was quenched with ice
2. 2
   추출extracted with ethyl acetate
3. 3
   건조dried (Na2SO4)
4. 4
   여과filtered
5. 5
   농축concentrated

실험 절차

1-(10-Aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone mg, 2.1 mmol) was added to chlorosulfonic acid (2 mL, 30 mmol) and stirred for 5 minutes. The mixture was quenched with ice, extracted with ethyl acetate, dried (Na2SO4), filtered and concentrated to provide an oil (640 mg, 87%). (TLC 30% ethyl acetate/hexanes Rf 0.15).

출처