반응 #10201

반응 방정식

1-(4-Acetyl-5-hydroxy-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone

hydroxylamine HCl

sodium acetate

→

oil

수율 93.0%

2,2,2-Trifluoro-1-[4-hydroxy-5-(1-hydroxyimino-ethyl)-10-aza-tricyclo[6.3.1.02,7]-dodeca-2(7),3,5-trien-10-yl]-ethanone

수율 93.0%

용매

methanol

H2O

H2O

반응 조건

후처리

1. 1
   온도The mixture was cooled
2. 2
   추출extracted with ethyl acetate which
3. 3
   건조was dried (Na2SO4)
4. 4
   여과filtered
5. 5
   농축concentrated

실험 절차

1-(4-Acetyl-5-hydroxy-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone (190 mg, 0.605 mmol), hydroxylamine HCl (99 mg, 1.21 mmol) and sodium acetate (118 mg, 1.21 mmol) were combined in methanol (4 mL) and H2O (1 mL) and warmed to 65° C. for 18 hours. The mixture was cooled, diluted with H2O and extracted with ethyl acetate which was dried (Na2SO4), filtered and concentrated to provide a yellow oil (177 mg, 93%).

출처