반응 #10197

반응 방정식

NaHCO3

1-(10-Aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone

AcCl

aluminum chloride

→

1-(4-Acetyl-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone

용매

DCE

반응 조건

후처리

1. 1
   workup.STIRRINGAfter stirring 20 minutes the mixture
2. 2
   추출was extracted with CH2Cl2 (3×30 mL)
3. 3
   기타The organic layer was dried through a cotton plug
4. 4
   농축then concentrated to a orange-yellow oil (255 mg, 86%)

실험 절차

1-(10-Aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone (253 mg, 1.0 mmol) and AcCl (0.68 mL, 10 mmol) were dissolved in DCE (3 mL) and treated with aluminum chloride (AlCl3) (667 mg, 5.0 mmol). The resulting yellow mixture was stirred for 30 minutes then poured over ice and saturated aqueous NaHCO3 solution. After stirring 20 minutes the mixture was extracted with CH2Cl2 (3×30 mL). The organic layer was dried through a cotton plug then concentrated to a orange-yellow oil (255 mg, 86%).

출처