반응 #1018913

ord-d5fc2597a99e47fd8ea868aa52db0a37

반응 방정식

Cc1ccc2c(-c3ccc(Cl)cc3)c([C@H](OC(C)(C)C)C(=O)O)c(Cl)cc2n1
compound 1L
Cc1ccc2c(-c3ccc(Cl)cc3)c([C@H](OC(C)(C)C)C(=O)O)c(Cl)cc2n1
(S)-2-tert-butoxy-2-(7-chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl)acetic acid
Cc1ccc2c(Br)c([C@@H](CO)OC(C)(C)C)c(C)cc2n1
(S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyethanol
→
Cc1ccc2c(Br)c([C@H](OC(C)(C)C)C(=O)O)c(C)cc2n1
Compound 5G
Cc1ccc2c(Br)c([C@H](OC(C)(C)C)C(=O)O)c(C)cc2n1
(S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyacetic acid

반응물

Cc1ccc2c(-c3ccc(Cl)cc3)c([C@H](OC(C)(C)C)C(=O)O)c(Cl)cc2n1
compound 1L
Cc1ccc2c(-c3ccc(Cl)cc3)c([C@H](OC(C)(C)C)C(=O)O)c(Cl)cc2n1
(S)-2-tert-butoxy-2-(7-chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl)acetic acid
Cc1ccc2c(Br)c([C@@H](CO)OC(C)(C)C)c(C)cc2n1
(S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyethanol

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Compound 5G was prepared following the procedure used to prepare compound 1L of Example 1, except that (S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyethanol (5F) was used instead of compound 1K. LCMS-ESI+ (m/z): 366.1, 368.1 (M+H)+.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US09296758B2uspto-grants-2016_03