반응 #10187

반응 방정식

4-Butylamino-5-nitro-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-10-carboxlic acid tert-butyl ester

ammonium formate

→

oil

수율 100.3%

4-Butylamino-5-amino-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-10-carboxylic acid tert-butyl ester

수율 100.3%

용매

methanol

반응 조건

후처리

1. 1
   온도to reflux for 1 hour
2. 2
   여과then filtered through a Celite pad
3. 3
   농축concentrated
4. 4
   workup.ADDITIONThe solids were treated with saturated aqueous Na2CO3 solution
5. 5
   추출extracted with CH2Cl2 (3×30 mL)
6. 6
   기타dried by filtration through a cotton plug

실험 절차

4-Butylamino-5-nitro-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-10-carboxlic acid tert-butyl ester (460 mg, 1.27 mmol) was treated with ammonium formate (850 mg, 12.7 mmol) and 10%Pd(OH)2/C (50 mg) in methanol (20 mL) and brought to reflux for 1 hour then filtered through a Celite pad and concentrated. The solids were treated with saturated aqueous Na2CO3 solution, extracted with CH2Cl2 (3×30 mL) and dried by filtration through a cotton plug to give an oil (440 mg, 100%).

출처