반응 #10130

반응 방정식

5-Hydroxymethyl-furan-2-carbaldehyde

3-pentylamino-phthalic acid dimethyl ester

→

yellow oil

수율 76.0%

3-[(5-Hydroxymethyl-furan-2-ylmethyl)-amino]-phthalic acid dimethyl ester

수율 76.0%

반응 조건

후처리

1. 1
   기타The residue (oil) was purified by chromatography (SiO2, 40/60 ethyl acetate/hexanes)

실험 절차

5-Hydroxymethyl-furan-2-carbaldehyde (0.95 ml, 7.5 mmol) was treated in the same manner as described above for the synthesis of 3-pentylamino-phthalic acid dimethyl ester. The residue (oil) was purified by chromatography (SiO2, 40/60 ethyl acetate/hexanes) to give 0.97 g (76%) of yellow oil: 1H NMR (CDCl3) δ 7.35–7.27 (m, 1H), 7.05 (bs, 1H), 6.87–6.83 (m, 2H), 6.21 (d, J=3.1 Hz, 1H), 6.17 (d, J=3.2 Hz, 1H), 4.57 (s, 2H), 4.38 (bs, 2H) 3.86 (s, 3H), 3.83 (s, 3H), 1.98 (bs, 1H).

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