반응 #1011

반응 방정식

1-benzyl-4-chloro-1H-imidazo[4,5-c]pyridine

N-ethyl-3-piperidone

→

title compound

3-(1-Benzyl-4-chloro-1H-imidazo[4,5-c]pyridin-2-yl)-1-ethyl-piperidin-3ol

반응 조건

실험 절차

Following the procedure of Example 13 and using 1-benzyl-4-chloro-1H-imidazo[4,5-c]pyridine (0.60 g, 2.5 mmol) and (0.36 g, 2.8 mmol) of N-ethyl-3-piperidone gave the free base of the title compound which was purified by flash chromatography on silica gel eluting with EtOAc to give, after preparation of the salt, the dihydrochloride, 0.59 hydrate as an amorphous solid, 0.30 g (26%):

출처