반응 #1010

반응 방정식

hydrochloride

1-benzyl-4-chloro-1H-imidazo[4,5-c]pyridine

3-quinuclidinol

→

title compound

수율 48.6%

3-(1-Benzyl-1H-imidazo[4,5-c]pyridin-4-yloxy)-1-aza-bicyclo[2,2,2]octane

수율 48.6%

반응 조건

실험 절차

Following the procedure of Example 1, 1-benzyl-4-chloro-1H-imidazo[4,5-c]pyridine (0.78 g, 3.2 mmol) was treated with 3-quinuclidinol (0.44 g, 3.5 mmol) to give 0.52 g (39%) of the title compound as the hydrochloride, 2.5 hydrate: mp 162°-183° C.

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