반응 #1009626

반응 방정식

7-hydroxy-1-tetralone

1-bromo-3-methoxypropane

potassium iodide

potassium carbonate

→

7-(3-methoxypropoxy)-3,4-dihydronaphthalen-1(2H)-one

용매

water

acetonitrile

반응 조건

후처리

1. 1
   온도the mixture was heated
2. 2
   온도cooling
3. 3
   추출the mixture was extracted with ethyl acetate
4. 4
   세척The organic layer was washed with saturated saline
5. 5
   건조dried over sodium sulfate
6. 6
   농축concentrated under reduced pressure
7. 7
   기타The resulting residue was triturated with n-hexane

실험 절차

To a solution of 7-hydroxy-1-tetralone (4.05 g) in acetonitrile (75 mL) were added 1-bromo-3-methoxypropane (4.59 g), potassium iodide (415 mg) and potassium carbonate (5.18 g), and the mixture was heated to stir at 80° C. for 23 hours. To the reaction mixture was added water under ice-cooling, and then the mixture was extracted with ethyl acetate. The organic layer was washed with saturated saline, dried over sodium sulfate, and then concentrated under reduced pressure. The resulting residue was triturated with n-hexane to give 7-(3-methoxypropoxy)-3,4-dihydronaphthalen-1(2H)-one [REx(12-1)] (4.70) as a colorless powder.

출처