반응 #1007322

반응 방정식

(RS)-5-(2-fluoro-phenyl)-5-methyl-imidazolidine-2,4-dione

sodium hydroxide

(RS)-2-amino-2-(2-fluoro-phenyl)-propionic acid

thionylchloride

→

(RS)-2-amino-2-(2-fluoro-phenyl)-propionic acid methylester

용매

methanol

반응 조건

실험 절차

The hydrolysis of the (RS)-5-(2-fluoro-phenyl)-5-methyl-imidazolidine-2,4-dione with 3 N sodium hydroxide solution and esterification of the resulting (RS)-2-amino-2-(2-fluoro-phenyl)-propionic acid with methanol and thionylchloride yielded the (RS)-2-amino-2-(2-fluoro-phenyl)-propionic acid methylester as a light yellow liquid. The purity of the product allowed using it in the next step without further purification. MS (ISP): m/z=198.2 [M+H]+.

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