반응 #1005983

반응 방정식

Compound 47

N-(4-chlorobutyl)-N-methyl-4-phenyl-1H-imidazole-1-carboxamide

tetra-n-butylammonium azide

→

N-(4-azidobutyl)-N-methyl-4-phenyl-1H-imidazole-1-carboxamide

용매

acetone

반응 조건

후처리

1. 1
   온도the reaction was refluxed for 8 h
2. 2
   기타solvent was evaporated on Rotavapor
3. 3
   기타to give a crude compound which
4. 4
   기타on purification by Biotage SP1

실험 절차

Compound 47 (4.3) (1 mmol) was taken in anhydrous acetone (25 mL) and tetra-n-butylammonium azide (2 mmol) was added and the reaction was refluxed for 8 h. The reaction was cooled to RT and solvent was evaporated on Rotavapor to give a crude compound which on purification by Biotage SP1 provided pure N-(4-azidobutyl)-N-methyl-4-phenyl-1H-imidazole-1-carboxamide (48/4.4).

출처