반응 #1005966

반응 방정식

3-chloroperoxybenzoic acid

2-(2-ethylsulfanylphenyl)-6-trifluoromethyl-imidazo[1,2-a]pyridine

sodium thiosulfate

→

2-(2-ethylsulfonylphenyl)-6-trifluoromethyl-imidazo[1,2-a]pyridine

용매

chloroform

반응 조건

후처리

1. 1
   추출the mixture was extracted with chloroform
2. 2
   세척The organic layer was washed with a saturated aqueous sodium bicarbonate solution
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   농축concentrated under reduced pressure

실험 절차

552 mg of 3-chloroperoxybenzoic acid (purity of 65% or more) was added to a mixture of 370 mg of 2-(2-ethylsulfanylphenyl)-6-trifluoromethyl-imidazo[1,2-a]pyridine and 5 ml of chloroform under ice cooling, and the mixture was stirred at room temperature for 2 hours. A 10% aqueous sodium thiosulfate solution was poured to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and dried over anhydrous magnesium sulfate, then concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 260 mg of 2-(2-ethylsulfonylphenyl)-6-trifluoromethyl-imidazo[1,2-a]pyridine (hereinafter, referred to as Compound of Present Invention 5).

출처