반응 #1005965

반응 방정식

2-bromo-6-trifluoromethyl-imidazo[1,2-a]pyridine

2-ethylsulfanylphenylboronic acid pinacol ester

tricyclohexylphosphine

tripotassium phosphate

→

2-(2-ethylsulfanylphenyl)-6-trifluoromethyl-imidazo[1,2-a]pyridine

수율 89.1%

용매

water

1,4-dioxane

water

Ethyl acetate

반응 조건

후처리

1. 1
   여과the mixture was filtered
2. 2
   추출The aqueous layer of the filtrate was extracted with ethyl acetate
3. 3
   세척the mixture was washed with water
4. 4
   건조dried over anhydrous magnesium sulfate
5. 5
   농축The mixture was concentrated under reduced pressure

실험 절차

A mixture of 526 mg of 2-bromo-6-trifluoromethyl-imidazo[1,2-a]pyridine, 576 mg of 2-ethylsulfanylphenylboronic acid pinacol ester, 50 mg of tris(dibenzylideneacetone) dipalladium(0), 201 mg of tricyclohexylphosphine (18% toluene solution), 1.26 g of tripotassium phosphate, 4.5 ml of 1,4-dioxane and 1.5 ml of water was stirred at 100° C. for 2.5 hours. Ethyl acetate and water were poured to the cooled reaction mixture, and the mixture was filtered. The aqueous layer of the filtrate was extracted with ethyl acetate, then combined with the organic layer of the filtrate, and the mixture was washed with water and dried over anhydrous magnesium sulfate. The mixture was concentrated under reduced pressure, and the resulting residue was applied to a silica gel column chromatography to obtain 570 mg of 2-(2-ethylsulfanylphenyl)-6-trifluoromethyl-imidazo[1,2-a]pyridine (hereinafter, referred to as Compound of Present Invention 4).

출처