반응 #1005961

반응 방정식

2-(2-ethylsulfonylphenyl)-6-trifluoromethyl-2H-indazole

N-chlorosuccinimide

sodium thiosulfate

→

3-chloro-2-(2-ethylsulfonylphenyl)-6-trifluoromethyl-2H-indazole

수율 100.8%

용매

DMF

반응 조건

후처리

1. 1
   추출the mixture was extracted with t-butyl methyl ether
2. 2
   세척The organic layer was washed with water
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   농축concentrated under reduced pressure
5. 5
   세척The resulting residue was washed with n-hexane

실험 절차

A mixture of 226 mg of 2-(2-ethylsulfonylphenyl)-6-trifluoromethyl-2H-indazole, 86 mg of N-chlorosuccinimide and 2 ml of DMF was stirred at room temperature for 10 hours. A 10% aqueous sodium thiosulfate solution was poured to the reaction mixture, and the mixture was extracted with t-butyl methyl ether. The organic layer was washed with water and dried over anhydrous magnesium sulfate, then concentrated under reduced pressure. The resulting residue was washed with n-hexane to obtain 250 mg of 3-chloro-2-(2-ethylsulfonylphenyl)-6-trifluoromethyl-2H-indazole (hereinafter, referred to as Compound of Present Invention 3).

출처