반응 #1005957

반응 방정식

5-Bromoindan-1-one

Hydroxylammonium chloride

sodium acetate

→

5-bromo-N-hydroxyindan-1-imine

수율 95.2%

용매

methanol

water

반응 조건

후처리

1. 1
   추출extracted twice with ethyl acetate
2. 2
   세척washed with water
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   여과The desiccant was filtered
5. 5
   기타separated
6. 6
   기타the solvent was evaporated off under reduced pressure

실험 절차

5-Bromoindan-1-one (5.0 g) was dissolved in methanol. Hydroxylammonium chloride (2.5 g) and sodium acetate (2.9 g) were added to the solution at room temperature, and then stirred overnight. The reaction solution was diluted with water and extracted twice with ethyl acetate. The organic layers were combined, washed with water, and dried over anhydrous magnesium sulfate. The desiccant was filtered and separated, and then the solvent was evaporated off under reduced pressure to obtain 5-bromo-N-hydroxyindan-1-imine (5.1 g).

출처