반응 #1005946

반응 방정식

1-{4-[3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoro-methyl)phenyl}methanamine

6-chloronicotinic acid chloride

methylene chloride

pyridine

→

title compound

6-chloro-N-{4-[3-(3,5-dichlorophenyl)-3-(trifluoro-methyl)-pyrrolidin-1-yl]-2-(trifluoromethyl)benzyl}pyridine-3-carboxyamide

반응 조건

후처리

1. 1
   기타The solvent was evaporated off under reduced pressure
2. 2
   기타the residue was then purified by a column chromatography

실험 절차

1-{4-[3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoro-methyl)phenyl}methanamine (0.1 g) and 6-chloronicotinic acid chloride (0.04 g) were dissolved in methylene chloride (5 mL), and then pyridine (0.03 g) was added thereto. The resulting mixture was stirred at room temperature for one hour. The solvent was evaporated off under reduced pressure, and the residue was then purified by a column chromatography to obtain the title compound (0.1 g).

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