반응 #1005944

반응 방정식

3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidine

4-fluoro-2-trifluoromethylbenzonitrile

potassium carbonate

N,N-dimethylformamide

→

title compound

수율 42.5%

4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)-benzonitrile

수율 42.5%

용매

ethyl acetate

반응 조건

후처리

1. 1
   온도After cooling the mixture to room temperature
2. 2
   세척washed with water three times
3. 3
   건조The organic layer was dried over anhydrous magnesium sulfate
4. 4
   기타The solvent was evaporated off under reduced pressure
5. 5
   기타the residue was then purified by a column chromatography

실험 절차

3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidine (5.6 g), 4-fluoro-2-trifluoromethylbenzonitrile (4.5 g) and potassium carbonate (5.4 g) were added to N,N-dimethylformamide (50 mL), and the mixture was stirred at 110° C. for 4 hours. After cooling the mixture to room temperature, the solution was diluted with ethyl acetate and washed with water three times. The organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated off under reduced pressure, and the residue was then purified by a column chromatography to obtain the title compound (3.8 g).

출처