반응 #1004

반응 방정식

2-chloro-7-amino-1,8-napthyridine

sodium methoxide

→

2-methoxy-7-amino-1,8-naphthyridine

용매

methyl alcohol

반응 조건

후처리

1. 1
   온도to cool
2. 2
   여과filtered through Celite
3. 3
   농축concentrated in vacuo
4. 4
   기타the residue purified on Silica gel (1:9:0.2 methyl alcohol/dichloromethane/ammonium hydroxide)

실험 절차

A mixture of 2-chloro-7-amino-1,8-napthyridine (Newkome, G. R. et al, J. Org. Chem., 1981, 46, 833-39) (180 mg, 1 mmol) and a methanolic solution of sodium methoxide (458 μL, 25 wt. %) in methyl alcohol (2 mL) was heated at 50° C. for 19 hours. The reaction mixture was allowed to cool, filtered through Celite using dichloromethane, concentrated in vacuo and the residue purified on Silica gel (1:9:0.2 methyl alcohol/dichloromethane/ammonium hydroxide) to afford 2-methoxy-7-amino-1,8-naphthyridine as a pale yellow solid.

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