반응 #10039

반응 방정식

Potassium thioacetate

methyl (2S,4R)-4-methylsulfonyloxy-1-methyl-2-pyrrolidinecarboxylate

Ethyl acetate

sodium chloride

→

title compound

수율 97.4%

Methyl (2S, 4S)-4-acetylthio-1-methyl-2-pyrrolidinecarboxylate

수율 97.4%

용매

ethanol water

반응 조건

후처리

1. 1
   workup.WAITto stand overnight at the same temperature
2. 2
   추출was then extracted
3. 3
   기타The organic layer was separated from the aqueous layer, which
4. 4
   세척was washed with water (10 mL)
5. 5
   기타The solvent of the organic layer was removed by distillation under reduced pressure

실험 절차

Potassium thioacetate (677 mg) was added to a solution of methyl (2S,4R)-4-methylsulfonyloxy-1-methyl-2-pyrrolidinecarboxylate (609 mg) obtained from Reference example 4 in ethanol/water (9:1) (6 ml), and the resulting mixture was stirred at 80° C. for 3 hours, and then the mixture was allowed to stand overnight at the same temperature. Ethyl acetate (20 mL) and 10% aqueous sodium chloride solution (10 mL) were added to the reaction mixture, which was then extracted. The organic layer was separated from the aqueous layer, which was washed with water (10 mL). The solvent of the organic layer was removed by distillation under reduced pressure to give the title compound (543 mg, yield 97%).

출처