반응 #1002045

반응 방정식

sodium carbonate

3-methoxypyrazine-2-carboxaldehyde

4-[2-(benzofuran-7-yl)ethyl]piperidine hydrochloride

sodium triacetoxyborohydride

→

title compound

수율 82.4%

3-[4-[2-(Benzofuran-7-yl)ethyl]piperidino]methyl-2-methoxypyrazine

수율 82.4%

용매

ethyl acetate

tetrahydrofuran

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   세척The organic layer was washed with water and saturated brine in that order
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
5. 5
   기타The residue was purified by silica gel column chromatography (solvent: n-hexane/ethyl acetate)

실험 절차

After adding 124 mg of 3-methoxypyrazine-2-carboxaldehyde and 200 mg of 4-[2-(benzofuran-7-yl)ethyl]piperidine hydrochloride to 3 ml of tetrahydrofuran, 238 mg of sodium triacetoxyborohydride was added and the mixture was stirred overnight at room temperature. Aqueous sodium carbonate solution was added to the reaction mixture and extraction was performed with ethyl acetate. The organic layer was washed with water and saturated brine in that order and dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (solvent: n-hexane/ethyl acetate) to obtain the title compound (218 mg, 82% yield).

출처