반응 #1000751

반응 방정식

5-Bromo-4-chloro-2-ethyl-1H-benzimidazole

CuCN

→

title compound

수율 35.5%

4-Chloro-2-ethyl-1H-benzimidazole-5-carbonitrile

수율 35.5%

용매

NMP

반응 조건

후처리

1. 1
   기타The cooled mixture was partitioned between Et2O and water
2. 2
   세척The organic portion was washed with brine
3. 3
   건조dried (Na2SO4)
4. 4
   여과filtered
5. 5
   농축concentrated in vacuo
6. 6
   기타Purification (SiO2, EtOAc/hexanes)

실험 절차

5-Bromo-4-chloro-2-ethyl-1H-benzimidazole (0.050 g, 0.192 mmol) and CuCN (0.030 g, 0.576 mmol) were combined in NMP (3 mL) and heated to 220° C. for 20 min in a microwave. The cooled mixture was partitioned between Et2O and water. The organic portion was washed with brine, dried (Na2SO4), filtered, and concentrated in vacuo. Purification (SiO2, EtOAc/hexanes) afforded the title compound (0.014 g): MS (ESI) m/z 206 (M+1).

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