반응 #1000750

반응 방정식

5-Bromo-4-chloro-2-ethyl-1H-benzimidazole

Cs2CO3

3-(chloromethyl)-5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole

→

title compound

수율 138.0%

5-Bromo-4-chloro-2-ethyl-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-benzimidazole

수율 138.0%

용매

DMF

반응 조건

후처리

1. 1
   기타The reaction mixture was partitioned between Et2O and water
2. 2
   세척The combined organic portions were washed with brine
3. 3
   건조dried (Na2SO4)
4. 4
   여과filtered
5. 5
   농축concentrated in vacuo
6. 6
   기타Purification (SiO2, EtOAc/hexanes)

실험 절차

5-Bromo-4-chloro-2-ethyl-1H-benzimidazole (0.100 g, 0.385 mmol), Cs2CO3 (0.188 g, 0.578 mmol), and 3-(chloromethyl)-5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole (0.152 g, 0.578 mmol) were combined in DMF (10 mL) and heated to 90° C. for 30 min. The reaction mixture was partitioned between Et2O and water. The combined organic portions were washed with brine, dried (Na2SO4), filtered, and concentrated in vacuo. Purification (SiO2, EtOAc/hexanes) provided the title compound 0.258 g: MS (ESI) m/z 487 (M+1).

출처