4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CN3CCN(CCO)CC3)ccc21

Reaction #49290

4-chloro-7-(1-(tert-butoxycarbonyl)-5-[4-(2-hydroxyethyl)piperazin-1-ylmethyl]indol-2-yl)isoindolinone

수율 111.9%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CNCCN3CCOCC3)ccc21

Reaction #49291

4-chloro-7-(1-(tert-butoxycarbonyl)-5-[(2-morpholinoethyl)aminomethyl]indol-2-yl)isoindolinone

수율 107.6%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CN(CCO)CCO)ccc21

Reaction #49292

4-chloro-7-(1-(tert-butoxycarbonyl)-5-[di(2-hydroxyethyl)aminomethyl]indol-2-yl)isoindolinone

수율 64.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CN3CCCCC3)ccc21

Reaction #49293

4-chloro-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone

수율 74.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CNCCO)ccc21

Reaction #49294

4-chloro-7-(1-(tert-butoxycarbonyl)-5-[(2-hydroxyethyl)aminomethyl]indol-2-yl)isoindolinone

수율 88.7%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CN(C)CCNCc1ccc2c(c1)cc(-c1ccc(Cl)c3c1C(=O)NC3)n2C(=O)OC(C)(C)C

Reaction #49295

4-chloro-7-(1-(tert-butoxycarbonyl)-5-[(2-dimethylaminoethyl)aminomethyl]indol-2-yl)isoindolinone

수율 109.5%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CCOC(=O)CNCc1ccc2c(c1)cc(-c1ccc(Cl)c3c1C(=O)NC3)n2C(=O)OC(C)(C)C

Reaction #49296

4-chloro-7-[1-(tert-butoxycarbonyl)-5-(ethoxycarbonylmethylaminomethyl)indol-2-yl]isoindolinone

수율 107.8%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CN3CCCC3)ccc21

Reaction #49298

4-chloro-7-[1-(tert-butoxycarbonyl)-5-(pyrrolidin-1-ylmethyl)indol-2-yl]isoindolinone

수율 103.8%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CN3CCOCC3)ccc21

Reaction #49299

4-chloro-7-[1-(tert-butoxycarbonyl)-5-(morpholinomethyl)indol-2-yl]isoindolinone

수율 103.7%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CN(C)Cc1ccc2c(c1)cc(-c1ccc(Cl)c3c1C(=O)NC3)n2C(=O)OC(C)(C)C

Reaction #49300

4-chloro-7-[1-(tert-butoxycarbonyl)-5-(dimethylaminomethyl)indol-2-yl]isoindolinone

수율 117.7%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CNCC(N)=O)ccc21

Reaction #49301

4-chloro-7-{1-(tert-butoxycarbonyl)-5-[(aminocarbonylmethyl)aminomethyl]indol-2-yl}isoindolinone

수율 120.6%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CN3CCC(CO)CC3)ccc21

Reaction #49302

4-chloro-7-[1-(tert-butoxycarbonyl)-5-[4-(hydroxymethyl)piperidinomethyl]indol-2-yl]isoindolinone

수율 106.6%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CN3CCC(CCO)CC3)ccc21

Reaction #49303

4-chloro-7-{1-(tert-butoxycarbonyl)-5-[4-(2-hydroxyethyl)piperidinomethyl]indol-2-yl}isoindolinone

수율 110.3%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CN3CCNC(=O)C3)ccc21

Reaction #49304

4-chloro-7-[1-(tert-butoxycarbonyl)-5-(3-oxopiperazin-1-ylmethyl)indol-2-yl]isoindolinone

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

COC(=O)C1CCN(Cc2ccc3c(c2)cc(-c2ccc(Cl)c4c2C(=O)NC4)n3C(=O)OC(C)(C)C)CC1

Reaction #49305

4-chloro-7-[1-(tert-butoxycarbonyl)-5-(4-methoxycarbonylpiperidinomethyl)indol-2-yl]isoindolinone

수율 70.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CCNCc1ccc2c(c1)cc(-c1ccc(Cl)c3c1C(=O)NC3)n2C(=O)OC(C)(C)C

Reaction #49306

4-chloro-7-[1-(tert-butoxycarbonyl)-5-(ethylaminomethyl)indol-2-yl]isoindolinone

수율 83.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CN3CCCCC3CO)ccc21

Reaction #49307

4-chloro-7-{1-(tert-butoxycarbonyl)-5-[2-(hydroxymethyl)piperidinomethyl]indol-2-yl}isoindolinone

수율 57.2%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CC1CCN(Cc2ccc3c(c2)cc(-c2ccc(Cl)c4c2C(=O)NC4)n3C(=O)OC(C)(C)C)CC1

Reaction #49308

4-chloro-7-[1-(tert-butoxycarbonyl)-5-(4-methylpiperidinomethyl)indol-2-yl]isoindolinone

수율 51.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CN3CCC(Br)CC3)ccc21

Reaction #49309

4-chloro-7-[1-(tert-butoxycarbonyl)-5-(4-bromopiperidinomethyl)indol-2-yl]isoindolinone

수율 133.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CN3CCN(S(C)(=O)=O)CC3)ccc21

Reaction #49310

4-chloro-7-{1-(tert-butoxycarbonyl)-5-[4-(methylsulfonyl)piperazin-1-ylmethyl]indol-2-yl}isoindolinone

수율 121.3%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

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