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198678

Cc1nc(N)nc2c1C(=NOCCC1COC(C)(C)O1)NC(c1ccc(F)cc1Br)C2

Reaction #201535

DOI: 10.1039/C8SC04228D

Cc1nc(N)nc2c1C(=NOCC1COCCO1)NC(c1ccc(F)cc1Br)C2

Reaction #222072

DOI: 10.1039/C8SC04228D

COC(=O)C1CC(ON=C2NC(c3ccc(F)cc3Br)Cc3nc(N)nc(C)c32)CN1C(=O)OC(C)(C)C

Reaction #250110

DOI: 10.1039/C8SC04228D

Cc1nc(N)nc2c1C(=NOCC1COC(C)(C)O1)NC(c1ccc(F)cc1Br)C2

Reaction #275852

DOI: 10.1039/C8SC04228D

Cc1nc(N)nc2c1/C(=N/OC[C@H]1COC(C)(C)O1)N[C@@H](c1ccc(F)cc1Br)C2

Reaction #743764

(R,Z)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one O—((R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl oxime

수율 30.0%DOI: 10.6084/m9.figshare.5104873.v1

Cc1nc(N)nc2c1/C(=N/OCC[C@H]1COC(C)(C)O1)N[C@@H](c1ccc(F)cc1Br)C2

Reaction #743766

(R,Z)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one O-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl oxime

수율 65.0%DOI: 10.6084/m9.figshare.5104873.v1

Cc1nc(N)nc2c1/C(=N/OC[C@H]1COCCO1)N[C@@H](c1ccc(F)cc1Br)C2

Reaction #743767

(R,Z)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one O—((R)-1,4-dioxan-2-yl)methyl oxime

수율 319.3%DOI: 10.6084/m9.figshare.5104873.v1

$COC(=O)[C@H](CCO/N=C1\N[C@@H](c2ccc(F)cc2Br)Cc2nc(N)nc(C)c21)OC$

Reaction #743769

(S)-methyl 4-((Z)—((R)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-ylidene)aminooxy)-2-methoxybutanoate

수율 12.0%DOI: 10.6084/m9.figshare.5104873.v1

$COC(=O)[C@@H]1C[C@@H](O/N=C2\N[C@@H](c3ccc(F)cc3Br)Cc3nc(N)nc(C)c32)CN1C(=O)OC(C)(C)C$

Reaction #743773

(2S,4R)-1-tert-butyl 2-methyl 4-((Z)—((R)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-ylidene)aminooxy)pyrrolidine-1,2-dicarboxylate

수율 570.0%DOI: 10.6084/m9.figshare.5104873.v1

$COC(=O)[C@@H]1C[C@@H](O/N=C2\N[C@@H](c3ccc(F)cc3Br)Cc3nc(N)nc(C)c32)CN1C(=O)OC(C)(C)C$

Reaction #743774

(2S,4R)-1-tert-butyl 2-methyl 4-((Z)—((R)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-ylidene)aminooxy)pyrrolidine-1,2-dicarboxylate

수율 570.0%DOI: 10.6084/m9.figshare.5104873.v1

Cc1nc(N)nc2c1/C(=N/O[Si](C)(C)C(C)(C)C)N[C@@H](c1ccc(F)cc1Br)C2

Reaction #743779

(R,Z)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one O-tert-butyldimethylsilyloxime

수율 80.0%DOI: 10.6084/m9.figshare.5104873.v1

Cc1nc(N)nc2c1/C(=N/OCCN1CCOCC1)N[C@@H](c1ccc(F)cc1Br)C2

Reaction #743782

(R,Z)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one O-2-morpholinoethyl oxime

수율 100.0%DOI: 10.6084/m9.figshare.5104873.v1

Cc1nc(N)nc2c1/C(=N/O[Si](C)(C)C(C)(C)C)N[C@@H](c1ccc(F)cc1Br)C2

Reaction #743807

(R,Z)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one O-tert-butyldimethylsilyloxime

수율 80.0%DOI: 10.6084/m9.figshare.5104873.v1

COC(=O)C(CCON=C1NC(c2ccc(F)cc2Br)Cc2nc(N)nc(C)c21)OC

Reaction #1636931

DOI: 10.1039/C8SC04228D

Cc1nc(N)nc2c1C(=NOCCN1CCOCC1)NC(c1ccc(F)cc1Br)C2

Reaction #1660833

DOI: 10.1039/C8SC04228D

Cc1nc(N)nc2c1/C(=N/OC[C@H]1COC(C)(C)O1)N[C@@H](c1ccc(F)cc1Br)C2

Reaction #2004662

(R,Z)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one O—((R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl oxime

수율 30.0%DOI: 10.6084/m9.figshare.5104873.v1

Cc1nc(N)nc2c1/C(=N/OCC[C@H]1COC(C)(C)O1)N[C@@H](c1ccc(F)cc1Br)C2

Reaction #2004664

(R,Z)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one O-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl oxime

수율 65.0%DOI: 10.6084/m9.figshare.5104873.v1

Cc1nc(N)nc2c1/C(=N/OC[C@H]1COCCO1)N[C@@H](c1ccc(F)cc1Br)C2

Reaction #2004665

(R,Z)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one O—((R)-1,4-dioxan-2-yl)methyl oxime

수율 319.3%DOI: 10.6084/m9.figshare.5104873.v1

$COC(=O)[C@H](CCO/N=C1\N[C@@H](c2ccc(F)cc2Br)Cc2nc(N)nc(C)c21)OC$

Reaction #2004667

(S)-methyl 4-((Z)—((R)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-ylidene)aminooxy)-2-methoxybutanoate

수율 12.0%DOI: 10.6084/m9.figshare.5104873.v1

Cc1nc(N)nc2c1/C(=N/OC[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OC(C)(C)C)N[C@@H](c1ccc(F)cc1Br)C2

Reaction #2004670

(2S,4R)-tert-butyl 2-(((Z)—((R)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-(6H)-ylidene)aminooxy)methyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine-1-carboxylate

수율 58.8%DOI: 10.6084/m9.figshare.5104873.v1

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