1-bromo-3,5-difluorobenzene

COC(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

수율 39.9%750 AstraZeneca ELN dataset

COC(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

수율 58.1%750 AstraZeneca ELN dataset

COC(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

수율 41.6%750 AstraZeneca ELN dataset

CN(C)C(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

수율 51.2%750 AstraZeneca ELN dataset

CN(C)C(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

수율 49.3%750 AstraZeneca ELN dataset

COC(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

수율 66.2%750 AstraZeneca ELN dataset

COC(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

수율 71.9%750 AstraZeneca ELN dataset

COC(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

수율 67.3%750 AstraZeneca ELN dataset

COC(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

수율 52.2%750 AstraZeneca ELN dataset

COC(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

수율 65.9%750 AstraZeneca ELN dataset

COC(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

수율 67.0%750 AstraZeneca ELN dataset

COC(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

수율 56.0%750 AstraZeneca ELN dataset

CN(C)C(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

수율 33.8%750 AstraZeneca ELN dataset

Fc1cc(F)cc(-c2ccsc2)c1

3(3,5-difluorophenyl)thiophene

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-1998_03

CCCSc1cc(F)cc(Br)c1

Reaction #48704

1-bromo-3-fluoro-5-propylsulfanylbenzene

수율 90.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

COC(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

Reaction #69447

methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylate

수율 58.4%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_09

COC(=O)c1cc([C@H]2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1

Reaction #69464

methyl 8-[(2R)-1-(3,5-difluorophenyl)pyrrolidin-2-yl]-2-morpholino-4-oxo-chromene-6-carboxylate

수율 67.1%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_09

O=C(c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1)N1CCOCC1

Reaction #69467

8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

수율 149.9%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_09

COC(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCO[C@H](C)C3)cc(=O)c2c1

Reaction #69497

methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxylate

수율 61.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_09

CC1(C)OC(=O)Nc2ccc(-c3cc(F)cc(F)c3)cc21

Reaction #78989

6-(3,5-difluoro-phenyl)-4,4-dimethyl-1,4-dihydrobenzo-[d][1,3]oxazin-2-one

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2004_03

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