反応 #9996

反応方程式

2-chloro-9-ethyl-6-(3-trifluoromethyl-phenyl-amino)-9H-purine

3-amino-1-propanol

→

9-Ethyl-2-(3-hydroxy-propyl-amino)-6-(3-trifluoromethyl-phenyl-amino)-9H-purine

溶媒

ethyl acetate

反応条件

後処理

1. 1
   温度to cool
2. 2
   洗浄The organic phase is washed with water
3. 3
   乾燥dried over sodium sulfate
4. 4
   その他After removal of the solvent
5. 5
   その他the residue is recrystallized from ethyl acetate and diethyl ether

実験手順

200 mg (0.58 mmol) of 2-chloro-9-ethyl-6-(3-trifluoromethyl-phenyl-amino)-9H-purine and 2 ml of 3-amino-1-propanol are stirred at 140° C. for 2 h and the mixture is allowed to cool and is diluted with 60 ml of ethyl acetate. The organic phase is washed with water and dried over sodium sulfate. After removal of the solvent, the residue is recrystallized from ethyl acetate and diethyl ether. 9-Ethyl-2-(3-hydroxy-propyl-amino)-6-(3-trifluoromethyl-phenyl-amino)-9H-purine is obtained; m.p. 136–137° C.; FAB-MS: (M+H)+=381; Rf=0.7 (ethyl acetate:methanol=9:1).

出典