反応 #995376

反応方程式

1-methylpiperazine

bromo-[1,3,4]thiadiazol-2-ylamine

→

required compound

5-(4-Methyl-piperazin-1-yl)-[1,3,4]thiadiazol-2-ylamine

溶媒

n-propanol

反応条件

後処理

1. 1
   温度is heated
2. 2
   温度at reflux for 6 hours
3. 3
   その他is removed

実験手順

A mixture of 1-methylpiperazine (0.742 ml, 6.6 mmol) and bromo-[1,3,4]thiadiazol-2-ylamine (63a) (0.60 g, 3.3 mmol) in n-propanol (15 ml) is heated at reflux for 6 hours. After cooling to room temperature the solvent is removed and the residue is trituated with ethyl acetate and methanol to afford the required compound as a pink solid.

出典