反応 #993

反応方程式

Chloroacetylchloride

2-aminopyridine

diisopropylethylamine

→

brown solid

収率 80.1%

2-Chloro-N-(2-pyridinyl)acetamide

収率 80.1%

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他the temperature below 5° C
2. 2
   ろ過was filtered
3. 3
   洗浄washed with water
4. 4
   乾燥The organic layer was dried (MgSO4)
5. 5
   その他evaporated under reduced pressure

実験手順

Chloroacetylchloride (60 g, 0.53M) was added with stirring to a mixture of 2-aminopyridine (50 g, 0.53M) and diisopropylethylamine (75 ml, 0.53M) in dichloromethane (500 ml) keeping the temperature below 5° C. After the reaction mixture was warmed to room temperature it was filtered and washed with water. The organic layer was dried (MgSO4) and evaporated under reduced pressure to give 72.6 g of a brown solid.

出典