反応 #992706

反応方程式

5-aminouracil

4,4′-difluorobenzophenone

→

N-(5-uracil-yl)-4,4′-difluorobenzophenone imine

溶媒

—

hexanes

N-methylpyrrolidone N-cyclohexylpyrrolidone

反応条件

後処理

1. 1
   その他In a round bottom flask equipped with an overhead stirrer
2. 2
   workup.ADDITIONwas added to fully induce precipitation
3. 3
   その他the solid was isolated by filtration
4. 4
   その他twice recrystallized from isopropanol
5. 5
   洗浄The product was rinsed with isopropanol, suction
6. 6
   その他dried
7. 7
   その他vacuum dried in an oven overnight

実験手順

In a round bottom flask equipped with an overhead stirrer, 1.16 grams (0.009 mole) of 5-aminouracil was charged along with 6 grams (0.027 mole) of 4,4′-difluorobenzophenone and a N-methylpyrrolidone/N-cyclohexylpyrrolidone solvent mixture (50/50, 20 milliliters). The reaction mixture was then heated to 180° C. for 3 days. A charge of hexanes (100 milliliters) was added to fully induce precipitation, and the solid was isolated by filtration and twice recrystallized from isopropanol. The product was rinsed with isopropanol, suction dried, and vacuum dried in an oven overnight.

出典